In this episode we journey beyond Cannabis and the endocannabinoid system into the endocannabinoidome! The endocannabinoidome is a relatively new concept used to describe the vast hundreds of compounds involved in the functioning of endocannabinoids and cannabinoid receptors. Learn about how this concept of the endocannabinoidome was formed, what clinicians think about its discovery, and what we can expect from the future of endocannabinoidome research! Plus hear an often overlooked story about the origin of "the entourage effect" and how the concept has been redefined for popular culture.
Featuring a contribution from Raphael Mechoulam, PhD via email and relevant excerpts from behind-the-scenes episodes:
BTS #5 Ethan Russo, MD
BTS #31 The Doctors Knox
BTS #35 Vincenzo Di Marzo, PhD
Stay curious, and take it easy!
In this behind-the-scenes episode we join renowned endocannabinoid researcher Dr. Vincenzo Di Marzo, who has been studying endocannabinoids since their discovery in the late 1980s and 1990s. Dr. Di Marzo, along with his colleagues, originally proposed the concept of the endocannabinoid system, the entourage effect, and the endocannabinoidome. Currently Dr. Di Marzo is working on studying the relationships between endocannabinoids and the gut microbiome to better understand how cannabinoids may affect health through the gut. In our conversation we discuss Dr. Di Marzo’s fascination with endocannabinoids, how he conceptualizes the endocannabinoidome, common misunderstandings about endocannabinoids, how the concept of the “entourage effect” has evolved away from its original intended meaning, where the future of Cannabis research may be heading, and much more.
This was a career highlight of mine to be able to talk to Vincenzo and I am honored to share this conversation with you. Enjoy!
In this behind-the-scenes interview we sit down with Sher Ali Butt, the co-founder of CB Therapeutics, a company focused on biosynthesizing cannabinoids and psychedelics using fermentation. We talk about the science behind biosynthetic technology, why they have chosen to focus on psychedelics and cannabinoids, how biosynthesis compares to chemical synthesis techniques for producing compounds, why isolated compounds and complex herbal mixtures both have a place in healthcare, and much more!
Learn more about CB Therapeutics at www.cbthera.com